Lab Publications

Microglia pack a toolbox for life

Trends in Immunology

Kristine E. Zengeler & John R. Lukens

Suppressing activity in the lateral habenula improves arthritic and depressive-like symptoms in a model of rheumatoid arthritis

Brain, Behavior, and Immunity

Aman Mangalmurti & John R. Lukens

Emerging roles for ITAM and ITIM receptor signaling in microglial biology and Alzheimer's disease-related amyloidosis

Journal of Neurochemistry

Joshua D. Samuels, John R. Lukens, & Richard J. Price

CARD9 attenuates Aβ pathology and modifies microglial responses in an Alzheimer’s disease mouse model

Proceedings of the National Academy of Sciences (PNAS)

Hannah Ennerfelt, Coco Holliday, Daniel A. Shapiro, Kristine E. Zengeler, Ashley C. Bolte, Tyler K. Ulland, & John R. Lukens

The role of PIMT in Alzheimer's disease pathogenesis: A novel hypothesis

Alzheimer’s and Dementia

Angelo D’Alessandra, John R. Lukens, & James C. Zimring

The Alzheimer's disease risk factor INPP5D restricts neuroprotective microglial responses in amyloid beta-mediated pathology

Alzheimer’s and Dementia

Joshua D. Samuels, Katelyn A. Moore, Hannah Ennerfelt, Alexis M. Johnson, Adeline E. Walsh, Richard J. Price, & John R. Lukens

Engineering mighty microglia

Journal of Experimental Medicine

Adeline E. Walsh & John R. Lukens

Role of the caspase-8/RIPK3 axis in Alzheimer’s disease pathogenesis and Aβ-induced NLRP3 inflammasome activation

Journal of Clinical Investigation (JCI) Insight

Sushanth Kumar, Sakar Budhathoki, Christopher B. Oliveira, August D. Kahle, Yipkin Calhan, John R. Lukens, & Christopher D. Deppmann

The meningeal transcriptional response to traumatic brain injury and aging

eLife

Ashley C. Bolte, Daniel A. Shapiro, Wei Feng Ma, Katherine R. Bruch, Michael A. Kovacs, Ana Royo Marco, Hannah Ennerfelt, & John R. Lukens

Microglia rely on SYK signalling to mount neuroprotective responses in models of Alzheimer's disease and multiple sclerosis

Clinical and Translational Medicine

Hannah Ennerfelt & John R. Lukens

SSRI treatment modifies the effects of maternal inflammation on in utero physiology and offspring neurobiology

Brain, Behavior, and Immunity

Kristine E. Zengeler, Daniel A. Shapiro, Katherine R. Bruch, Catherine R. Lammert, Hannah Ennerfelt, & John R. Lukens

Harnessing the brain’s immune cells to stave off Alzheimer’s and other neurodegenerative diseases

The Conversation

Kristine Zengeler

SYK Coordinates Neuroprotective Microglial Responses in Neurodegenerative Disease

Cell

Hannah Ennerfelt, Elizabeth L. Frost, Daniel A. Shapiro, Coco Holliday, Kristine E. Zengeler, Gabrielle Voithofer, Ashley C. Bolte, Catherine R. Lammert, Josh A. Kulas, Tyler K. Ulland, & John R. Lukens

The nervous system during COVID-19: Caught in the crossfire

Immunological Reviews

Nick R. Natale, John R. Lukens, & William A. Petri, Jr.

Taking the Parkin Brakes Off of Neuronal NLRP3 Drives Inflammasome Activation and Neurodegeneration in Parkinson’s Disease

Neuron

Kristine E. Zengeler & John R. Lukens

How Neurons Die in Alzheimer's Disease: Implications for Neuroinflammation

Current Opinions in Neurobiology

Aman Mangulmurti & John R. Lukens

Neuroimmune Cleanup Crews in Brain Injury

Trends in Immunology

Ashley C. Bolte & John R. Lukens

Innate Immunity at the Crossroads of Healthy Brain Maturation and Neurodevelopmental Disorders

Nature Reviews Immunology

Kristine E. Zengeler & John R. Lukens

Inflammation Stresses Out Brain Development

Nature Neuroscience

Kristine E. Zengeler & John R. Lukens

Meningeal Lymphatic Dysfunction Exacerbates Traumatic Brain Injury Pathogenesis

Nature Communications

Ashley C. Bolte, Arun B. Dutta, Mariah E. Hurt, Igor Smirnov, Michael A. Kovacs, Celia A. McKee, Hannah E. Ennerfelt, Daniel Shapiro, Bao H. Nguyen, Elizabeth L. Frost, Catherine R. Lammert, Jonathan Kipnis & John R. Lukens

The Role of Innate Immunity in Alzheimer's Disease

Immunological Reviews

Hannah E. Ennerfelt & John R. Lukens

AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment

Nature

Catherine R. Lammert, Elizabeth L. Frost, Calli E. Bellinger, Ashley C. Bolte, Celia A. McKee, Mariah E. Hurt, Matt J. Paysour, Hannah E. Ennerfelt & John R. Lukens 

tRNA-derived fragments and microRNAs in the maternal-fetal interface of a mouse maternal-immune-activation autism model

RNA Biology

Zhangli Su, Elizabeth L. Frost, Catherine R. Lammert, Roza K. Przanowska, John R. Lukens* & Anindya Dutta*  

*-co-corresponding authors

NLRP3 sets the table for a parasitic meal

Journal of Leukocyte Biology

Sushanth Kumar & John R. Lukens

Modeling Autism-Related Disorders in Mice with Maternal Immune Activation (MIA)

DNA and Cell Biology

Catherine R. Lammert & John R. Lukens

Crosstalk Between the Microbiome and Gestational Immunity in Autism-Related Disorders

Methods in Molecular Biology

Matt J. Paysour MJ, Ashley C. Bolte, & John R. Lukens

Necroptosis and Apoptosis Contribute to Cisplatin and Aminoglycoside Ototoxicity

The Journal of Neuroscience

Ruhl D, Du TT, Wagner EL, Choi JH, Li S, Reed R, Kim K, Freeman M, Hashisaki G, Lukens JR, Shin JB.

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature

Nature Neuroscience

Louveau A, Herz J, Alme MN, Salvador AF, Dong MQ, Viar KE, Herod SG, Knopp J, Setliff JC, Lupi AL, Da Mesquita S, Frost EL, Gaultier A, Harris TH, Cao R, Hu S, Lukens JR, Smirnov I, Overall CC, Oliver G, Kipnis J

Th17 Cells in Parkinson's Disease: The Bane of the Midbrain

Cell Stem Cell

Ashley C. Bolte & John R. Lukens

Cutting Edge: Critical Roles for Microbiota-Mediated Regulation of the Immune System in a Prenatal Immune Activation Model of Autism

Journal of Immunology

Catherine R. Lammert, Elizabeth L. Frost, Ashley C. Bolte, Matt J. Paysour, Mariah E. Shaw, Calli E. Bellinger, Thaddeus K. Weigel, Eli R. Zunder, & John R. Lukens

NLR-Dependent Regulation of Inflammation in Multiple Sclerosis

Frontiers in Immunology

Gharagozloo M, Gris KV, Mahvelati T, Amrani A, Lukens JR, Gris D

Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.

Immunity

Gurung P, Fan G, Lukens JR, Vogel P, Tonks NK, Kanneganti TD

Oxidized Low-Density Lipoprotein Immune Complex Priming of the Nlrp3 Inflammasome Involves TLR and FcγR Cooperation and Is Dependent on CARD9

Journal of Immunology

Rhoads JP, Lukens JR, Wilhelm AJ, Moore JL, Mendez-Fernandez Y, Kanneganti TD, Major AS.

Emerging Roles for the Immune System in Traumatic Brain Injury

Frontiers in Immunology

Celia A. McKee & John R. Lukens

The brain's reward circuitry regulates immunity.

Nature Medicine

Elizabeth L. Frost & John R. Lukens

Dealing with Danger in the CNS: The Response of the Immune System to Injury

Neuron

Gadani SP, Walsh JT, Lukens JR, Kipnis J.

The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells.

Immunity

Lukens JR, Gurung P, Shaw PJ, Barr MJ, Zaki MH, Brown SA, Vogel P, Chi H, Kanneganti TD.

Dietary modulation of the microbiome affects autoinflammatory disease.

Nature

Lukens JR, Gurung P, Vogel P, Johnson GR, Carter RA, McGoldrick DJ, Bandi SR, Calabrese CR, Vande Walle L, Lamkanfi M, Kanneganti TD

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.

Nature

Lukens JR, Vogel P, Johnson GR, Kelliher MA, Iwakura Y, Lamkanfi M, Kanneganti TD.

Critical role for inflammasome-independent IL-1β production in osteomyelitis

Proceedings of the National Academy of Sciences USA

Lukens JR, Gross JM, Calabrese C, Iwakura Y, Lamkanfi M, Vogel P, Kanneganti TD